Сентябрь 5th, 2023 
raven000 Диабет — заболевание, ведущее к вечным инъекциям инсулина, инвалидности и трагическим осложнениям. Специалисты из Приволжского экспериментального лечебного института (ПИМУ) перешли к подготовке важно нового способа излечения этого недуга.
Чтобы осознать механизм технологии, стоит отметить о том, как функционирует поджелудочная железа, почему появляется диабет. В данном органе есть так именуемые бета-клетки, соединенные в островки, которые автоматом продуцируют инсулин в ответ на увеличение значения глюкозы в крови. При ряде аутоиммунных либо приобретенных заболеваний совместная их масса понижается, возникают многофункциональные нарушения в качестве недостающей выработки инсулина. Итог — увеличение значения глюкозы в сыворотке крови.
— Это инсулинопотребный диабет. Он появляется, если количество островков снизилось на 80 %, — сообщает управляющий кафедрой факультетской хирургии и трансплантологии, основной внештатный трансплантолог минздрава Нижегородской области Владимир Загайнов.
Эксперт выделяет, что способ излечения диабета лишь 1 — операция поджелудочной железы. Необходимость в данной процедуры в РФ довольствуется на тысячные части %, что имеет связь с недостатком донорских органов. Во всех других вариантах речь в данном случае идет о компенсации заболевания при помощи инсулина. Но даже трансплантация сопровождается потребностью иммуносупрессивной терапии, чтобы организм больного не отвергал донорский орган. У нее же есть собственные недостатки, в особенности в отдаленном времени.
Ключевая мысль проекта — трансплантация не всей поджелудочной железы, а лишь островков, заключающихся из тех бета-клеток.
— Островки будут выдаваться из донорской железы особым методом. Даже если целая железа не подходит для пересадки, из нее можно постараться отметить островки и трансплантировать их, — объясняет Владимир Загайнов.
Во всем мире данную мысль стараются осуществить различными методами и с различной ступенью удачливости. Внедрение островков от донора требует все той же опасной иммуносупрессивной терапии. В ПИМУ специалисты разрабатывают вариант трансплантации клеток, помещенных в особые ноздреватые капсулы. Теоретически клетки приживаются и начинают производить инсулин. Человек лечится от диабета. А поры капсулы довольно малы, чтобы отвести атаку защитных клеток организма, из-за этого никакой иммуносупрессивной терапии не требуется. Принципиально, что речь в данном случае идет о малоинвазивных операциях, а не о трудной пересадки. Вероятных видов несколько: внедрение в абдоминальную полость маршрутом пункции или внедрение в печень по вороновой вене.
Первые опыты экспертов из Институт опытной онкологии и биомедицинских технологий ПИМУ совместно с Факультетом металлоорганической химии РАН были удачными.
— В далекой возможности рассчитываем отработать разведение бета-клеток из стволовых, — говорит Владимир Загайнов. — Одновременно совместно с сослуживцами из Государственного лечебного экспериментального центра трансплантологии и искусственного происхождения органов имени Шумакова занимаемся легитимизацией технологии. Прежде в РФ за это никто не хватался, из-за этого операция островков бета-клеток поджелудочной пока не вошла в перечень разрешенных, впрочем во всем мире это есть. Предполагаем, что в скором времени вопрос будет постановлен.
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